Table 2.

IRA stability in whole brain of CD-1 mice

	Whole Brain		Olfactory Bulb		Serum
Single	AP%	Pcon %	AP%	Pcon %	AP%	Pcon %
Exenatide	70.2 ± 17.7	88.2	55.2 ± 0.5	91.1	55.1 ± 11.9	81.4
Semaglutide	74.7 ± 17.7	98.7 ± 0.0	100.9 ± 0.5	98.3 ± 0.1	86.9 ± 1.1	98.9 ± 0.1
Dual	AP%	Pcon%	AP%	Pcon %	AP%	Pcon %
DA4-JC	171.1 ± 6.2	53.4 ± 2.3	59.4 ± 38.7	56.7 ± 0.6	190.0 ± 6.5	43.7 ± 2.6
DA5-CH	51.0 ± 6.1	97.7 ± 2.0	82.8 ± 8.1	70.3 ± 1.5	42.5 ± 1.9	90.1 ± 0.6

Acid precipitation (AP%) means ± SEM 30 min after IN administration of ¹²⁵I/¹⁴C-IRAs in the whole brain (WB), olfactory bulb (OB), and serum (Ser). Data are expressed relative to processing controls (Pcon %, n = 2), which assesses stability due to processing only. Exenatide n = 3 M, semaglutide n = 2 M/2F, DA4-JC n = 3 M/3F, DA5-CH n = 4 M/4F. M = male, F = female