Figure 2.
Characterization of TCR repertoire landscape in patients with ovarian cancer
(A) Heatmap showing the distribution of the top 1,500 most variable RFUs of high-grade, low-grade, and benign patients.
(B) Distribution of patients with ovarian cancer and benign patients on the PCA plot calculated from the RFU-by-patient matrix.
(C) Violin plot showing the differences of PC1 across disease categories. Statistical significance was evaluated using one-way ANOVA.
(D) Distribution of patient races on the PCA plot.
(E) Violin plot showing the differences of PC2 across patient races. Statistical significance was evaluated using one-way ANOVA.
(F) Volcano plot showing the log odds ratio vs. FDR adjusted by Benjamini-Hochberg method. The odds ratio is estimated from logistic regression with disease status as a binary outcome, with each RFU being the covariate and adjusted for age and race. Blue: down-regulated; Red: up-regulated.
(G) Sequence logo analysis of selected top up-/down-regulated RFUs. Scale of logo height (y axis) was measured by bits ranging from 0 to 4.