Figure 6.

Lactococcus lactis^pNZ-Apyr administration improves gut microbiota selection in MAL newborns

(A) Chart summarizing the percent relative abundance of the cecal microbiota by order classification in the different experimental groups (n = 7–11 mice per group, one independent experiment).

(B and C) Statistical analysis of the relative abundance of Enterobacteriaceae (B) and Akkermansia (C) in the cecal microbiota in MAL or MAL mice treated with L. lactis^pNZ or L. lactis^pNZ-Apyr (n = 7–11 mice per group, one independent experiment, Mann-Whitney U test, data points represent individual mice, Mean ± SEM are shown, ∗p < 0.05; ∗∗p < 0.01).

(D) Heatmap showing bacterial ASVs in the cecal microbiota that discriminate 21-day-old MAL or MAL mice treated with L. lactis^pNZ or L. lactis^pNZ-Apyr. ASVs were selected according to p < 0.05 with Wald test using FDR p value correction following DESeq2 read counts normalization. Each line represents one ASV, and each column represents an individual mouse. Mean relative abundances (log10) of ASVs detected in the different experimental groups are shown.