Figure 5.
Heatmap of average Z scored blood plasma metabolites levels within each BMF category for all metabolites significantly associated with BMF
11 significant blood plasma metabolites, with average Z scores within each BMF category plotted as a heatmap. Significant associations were identified using LIMMA, with FDR-corrected p values of the ratio test between the main model and the null model. Here, the covariates included gender, age, BMI, eGFR, LDL, CRP, A1C, and PCs 1–3. Asterisks denote metabolites with significant βBMF coefficient(s) in the linear regression model after FDR correction. (∗∗∗): p < 0.0001, (∗∗): 0.0001 < p < 0.01, (∗): 0.01 < p < 0.05.