Figure 6.

Clinical phenotype of people with PSC carrying polymorphism rs56258221 (BACH2/MIR4464)

(A) Laboratory parameters and clinical features of people with PSC attending the outpatient clinic for gastroenterology and hepatology of the University Medical Centre Hamburg-Eppendorf (n = 210). The data were separated into carriers and non-carriers of rs56258221. Both groups span a similar time between diagnosis of PSC and collection of laboratory parameters (mean ± SD).

(B) Assessment of transplant-free survival between SNP carriers and non-carriers. The combined independent cohorts from University Medical Centre Hamburg-Eppendorf (Germany) and the Norwegian PSC Centre in Oslo (Norway) are shown. Survival data were analyzed by using log rank test. Tick marks represent censoring.