Table 5.
Comparison between baseline characteristics of MILR in 2361 cirrhosis patients with and without portal hypertension ()
| Entire unmatched cohort | 1:1 PSM (nearest neighbour matching) | 1:1 CEM | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| All (N = 2327) | Cirrhosis PHT (N = 626) | Cirrhosis NPHT (N = 1701) | P-value | Cirrhosis PHT (N = 450) | Cirrhosis NPHT (N = 450) | P-value | Cirrhosis PHT (N = 290) | Cirrhosis NPHT (N = 290) | P-value (paired) | |
|
| ||||||||||
| Median age (IQR), yrs | 63.00 [55.00, 71.00] | 63.00 [55.00, 71.00] | 63.00 [55.00, 71.00] | 0.734 | 62.00 [54.00, 70.00] | 64.00 [55.00, 70.00] | 0.217 | 61.00 [54.00, 69.00] | 62.00 [55.00, 69.00] | 0.607 |
|
| ||||||||||
| Male sex, n (%) | 1731 (74.4) | 468 (74.8) | 1263 (74.3) | 0.844 | 339 (75.3) | 335 (74.4) | 0.822 | 230 (79.3) | 230 (79.3) | NA |
|
| ||||||||||
| Median BMI (IQR) | 24.68 [22.22, 27.45] | 25.08 [22.84, 28.00] | 24.50 [22.10, 27.25] | <0.001 | 24.93 [22.50, 27.70] | 25.00 [22.49, 27.68] | 0.826 | 24.80 [22.70, 27.40] | 24.34 [22.16, 27.24] | 0.426 |
|
| ||||||||||
| Robotic, n (%) | 260 (11.2) | 56 (8.9) | 204 (12.0) | 43 (9.6) | 41 (9.1) | 12 (4.1) | 12 (4.1) | |||
| Laparoscopic, n (%) | 2067 (88.8) | 570 (91.1) | 1497 (88.0) | 0.046 | 407 (90.4) | 409 (90.9) | 0.907 | 278 (95.9) | 278 (95.9) | NA |
|
| ||||||||||
| Previous abdominal surgery, n (%) | 436 (19.7) | 142 (22.7) | 294 (18.5) | 0.028 | 98 (21.8) | 97 (21.6) | 1.000 | 36 (12.4) | 36 (12.4) | NA |
|
| ||||||||||
| Childs A, n (%) | 2082 (89.5) | 1581 (92.9) | 501 (80.0) | 392 (87.1) | 398 (88.4) | 280 (96.6) | 280 (96.6) | |||
| Childs B, n (%) | 245 (10.5) | 120 (7.1) | 125 (20.0) | 0.028 | 58 (12.9) | 52 (11.6) | 0.561 | 10 (3.4) | 10 (3.4) | NA |
|
| ||||||||||
| Year of surgery, n (%) | ||||||||||
| 2004–2009 | 144 (6.2) | 48 (7.7) | 96 (5.6) | 33 (7.3) | 37 (8.2) | 10 (3.4) | 10 (3.4) | |||
| 2010–2015 | 692 (29.7) | 173 (27.6) | 519 (30.5) | 121 (26.9) | 118 (26.2) | 92 (31.7) | 92 (31.7) | |||
| 2016–2021 | 1491 (64.1) | 405 (64.7) | 1086 (63.8) | 0.113 | 296 (65.8) | 295 (65.6) | 0.939 | 188 (64.8) | 188 (64.8) | NA |
|
| ||||||||||
| ASA score, n (%) | ||||||||||
| 1/2 | 1604 (69.0) | 393 (62.8) | 1211 (71.3) | 298 (66.2) | 297 (66.0) | 205 (70.7) | 205 (70.7) | |||
| 3/4 | 721 (31.0) | 233 (37.2) | 488 (28.7) | <0.001 | 152 (33.8) | 153 (34.0) | 1.000 | 85 (29.3) | 85 (29.3) | NA |
|
| ||||||||||
| Tumor type, n (%) | ||||||||||
| HCC | 2194 (94.3) | 613 (97.9) | 1581 (93.0) | 441 (98.0) | 440 (97.8) | 288 (99.3) | 288 (99.3) | |||
| ICC/ cholangiohepatoma | 132 (5.7) | 13 (2.1) | 119 (7.0) | <0.001 | 9 (2.0) | 10 (2.2) | 1.000 | 2 (0.7) | 2 (0.7) | NA |
|
| ||||||||||
| Median tumor size, mm (IQR) | 26.00 [20.00, 38.00] | 25.00 [18.00, 35.00] | 27.00 [20.00, 40.00] | <0.001 | 25.00 [18.00, 35.00] | 25.00 [20.00, 35.00] | 0.620 | 23.50 [18.00, 32.00] | 25.00 [19.25, 30.00] | 0.748 |
|
| ||||||||||
| Multiple tumors, n (%) | 228 (9.8) | 50 (8.0) | 178 (10.5) | 0.088 | 35 (7.8) | 32 (7.1) | 0.807 | 4 (1.4) | 4 (1.4) | NA |
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| ||||||||||
| Wedge/ partial liver resection, n (%) | 1420 (61.0) | 410 (65.5) | 1010 (59.4) | 291 (64.7) | 293 (65.1) | 199 (68.6) | 199 (68.6) | |||
| Segmentectomy, n (%) | 907 (39.0) | 216 (34.5) | 691 (40.6) | 0.008 | 159 (35.3) | 157 (34.9) | 0.942 | 91 (31.4) | 91 (31.4) | NA |
|
| ||||||||||
| Concomitant minor surgery excluding cholecystectomy, n (%) | 95 (4.1) | 31 (5.0) | 64 (3.8) | 0.242 | 22 (4.9) | 21 (4.7) | 1.000 | 5 (1.7) | 5 (1.7) | NA |
|
| ||||||||||
| Hilar lymph node dissection, n (%) | 9 (0.4) | 5 (0.8) | 4 (0.2) | 0.065 | 0 (0.0) | 1 (0.2) | 1.000 | 0 (0.0) | 0 (0.0) | NA |
|
| ||||||||||
| Median Iwate difficulty score, [IQR] (range) | 4.00 [3.00, 6.00] (1, 9) | 4.00 [2.00, 6.00] (1, 9) | 4.00 [3.00, 6.00] (1, 9) | 0.008 | 3.00 [2.00, 6.00] (1, 8) | 3.00 [2.00, 5.00] (1, 9) | 0.704 | 3.00 [2.00, 5.00] (1, 9) | 3.00 [2.00, 5.00] (1, 9) | NA |
|
| ||||||||||
| Iwate difficulty, n (%) | ||||||||||
| Low | 1097 (47.2) | 309 (49.4) | 788 (46.4) | 232 (51.6) | 233 (51.8) | 169 (58.3) | 169 (58.3) | |||
| Intermediate | 841 (36.2) | 236 (37.7) | 605 (35.6) | 152 (33.8) | 164 (36.4) | 97 (33.4) | 97 (33.4) | |||
| High | 388 (16.7) | 81 (12.9) | 307 (18.1) | 0.013 | 66 (14.7) | 53 (11.8) | 0.533 | 24 (8.3) | 24 (8.3) | NA |