Self-reported valence in response to emotional reactivity and regulation task stimuli. Reactivity refers to the contrast between viewing neutral images and negative images pre- and post-transcranial focused ultrasound (TFUS) targeting of the amygdala (yellow) vs. the entorhinal cortex (blue). Individual values are depicted as translucent dots. Valence was reported following 5 seconds of stimulus presentation using an ordinal scale ranging from 1 to 9, where 1 is unhappy and 9 is happy (see Figure S2A). Effects of factors pre/post (pre-TFUS, post-TFUS), TFUS target (amygdala, entorhinal cortex), and instructions (“VIEW” neutral images, “WATCH” negative images, “REAPPRAISE” negative images) on the self-reported valence of International Affective Picture System images. No effects including the factor pre/post were statistically significant (ps > .162). Thus, there were no effects on negative emotional reactivity or negative emotional regulation. Reappraisal refers to the contrast between viewing negative images and reappraising negative images. Complete data is available in Table S3B.