Figure 5.

A novel readthrough transcript of CASP1

(A) USCS genome browser track of the transcripts detected in the control condition (RPMI) and stimulated condition (poly(I:C)). The novel readthrough transcript containing both CASP1 and CARD16 is presented in light blue. Known transcripts in in GENCODE are presented below.

(B) Representation of the domains in the novel CASP1 transcript, indicating that CARD16 is entirely included in the 5′ UTR of the transcript.

(C) Gene and (D) transcript expression and (E) isoform fraction of the CASP1 transcripts that were detected (∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant).