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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Nature. 2023 Dec 11;625(7996):778–787. doi: 10.1038/s41586-023-06903-x

Extended Data Figure 5: Mutual exclusivity/ co-association analysis using the DISCOVER R-package.

Extended Data Figure 5:

Heatmaps summarizing (A) unadjusted -log10 p-values or (B) -log10 q-values for mutual exclusivity/ co-association, respectively. Alterations that tend to co-occur are visualized in blue, while those with a tendency for mutual exclusivity are depicted in red colors. Non-silent mutations and SCNA as summarized in the LDA clustering matrix observed in >20 patients among 293 cases were included in the analysis. Statistics were performed using the DISCOVER R-package.