Table 2.
Frequency of Autoantibodies in Each Cluster Over Time
| Cluster 1 (n=137) | Cluster 2 (n=376) | Cluster 3 (n=80) | Cluster 4 (n=212) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antibody | Enrolment | Y3 | Y5 | Enrolment | Y3 | Y5 | Enrolment | Y3 | Y5 | Enrolment | Y3 | Y5 |
| Sm | 78.8 | 69.3 | 50.4 | 5.3 | 1.3 | 3.2 | 11.3 | 6.3 | 6.3 | 21.7 | 10.4 | 15.1 |
| U1RNP | 95.6 | 90.5 | 74.5 | 8.8 | 6.6 | 6.6 | 12.5 | 10.0 | 12.5 | 25.0 | 19.3 | 22.6 |
| DFS70 | 1.5 | 1.5 | 2.2 | 8.8 | 9.8 | 9.6 | 5.0 | 5.0 | 3.8 | 4.7 | 4.8 | 2.8 |
| β2GP1 IgG | 4.4 | 4.4 | 3.7 | 4.8 | 4.3 | 3.7 | 46.3 | 40.0 | 40.0 | 7.1 | 5.2 | 9.0 |
| β2GP1 IgM | 9.5 | 9.5 | 2.2 | 9.6 | 10.9 | 3.5 | 46.3 | 46.3 | 31.3 | 10.4 | 13.2 | 3.3 |
| Cardiolipin IgG | 13.1 | 6.6 | 12.4 | 8.0 | 3.7 | 6.4 | 55.0 | 37.5 | 37.5 | 20.3 | 7.1 | 13.7 |
| Cardiolipin IgM | 1.5 | 1.5 | 2.2 | 5.1 | 2.9 | 4.8 | 33.8 | 22.5 | 23.8 | 2.4 | 4.2 | 3.3 |
| β2GP1-Domain 1 | 6.6 | 4.4 | 3.7 | 6.4 | 4.0 | 2.7 | 45.0 | 50.1 | 47.5 | 6.6 | 4.7 | 4.7 |
| Lupus anticoagulant | 8.61 | 10.72 | 8.61 | 16.03 | 12.44 | 8.33 | 64.85 | 70.26 | 60.65 | 15.07 | 14.58 | 10.67 |
| PS/PT IgG | 15.3 | 19.0 | 10.9 | 9.8 | 8.8 | 5.9 | 71.3 | 63.8 | 61.3 | 21.7 | 25.0 | 20.3 |
| PS/PT IgM | 19.0 | 16.8 | 13.9 | 17.6 | 16.5 | 8.2 | 78.8 | 77.5 | 62.5 | 27.8 | 20.3 | 16.0 |
| dsDNA | 35.0 | 38.7 | 33.6 | 18.9 | 11.2 | 9.3 | 36.3 | 41.3 | 40.0 | 59.0 | 56.1 | 56.1 |
| Histone | 29.2 | 21.2 | 21.2 | 15.7 | 6.9 | 10.9 | 33.8 | 21.3 | 26.3 | 59.4 | 46.7 | 43.4 |
| PCNA | 16.8 | 10.2 | 13.9 | 7.4 | 4.8 | 12.8 | 17.5 | 6.3 | 18.8 | 29.2 | 18.4 | 31.1 |
| Ribosomal P | 33.6 | 28.5 | 26.3 | 11.4 | 6.1 | 8.5 | 23.8 | 15.0 | 18.8 | 41.5 | 36.3 | 36.8 |
| Ro52/TRIM21 | 39.4 | 29.9 | 37.2 | 22.3 | 18.1 | 21.3 | 16.3 | 17.5 | 25.0 | 71.2 | 69.8 | 70.8 |
| SSA/Ro60 | 48.9 | 42.3 | 46.0 | 25.5 | 22.3 | 26.3 | 21.3 | 21.3 | 25.0 | 76.4 | 79.7 | 73.6 |
| SSB/La | 15.3 | 7.3 | 8.0 | 8.8 | 6.9 | 9.0 | 12.5 | 8.8 | 13.8 | 48.6 | 39.6 | 35.4 |
| Centromere B | 2.9 | 0.7 | 4.4 | 0.8 | 1.1 | 2.1 | 3.8 | 3.8 | 6.3 | 5.7 | 6.6 | 11.8 |
| Jo-1 | 0.0 | 0.7 | 0.7 | 1.1 | 1.3 | 2.4 | 1.3 | 0.0 | 7.5 | 3.3 | 0.9 | 6.6 |
Darker red shading indicates higher frequency, lighter shading indicates lower frequency of autoantibody
1
n=116 complete data,
2
n=84,
3
n=337,
4
n=237,
5
n=71,
6
n=47,
7
n=180,
8
n=117