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Hypoxanthine supplementation of regular media enhances leukemia cell resistance to thiopurines. 6-MP (A–E) and 6-TG (F–J) dose-response curves for leukemia cells (NALM-6, A, F; REH, B, G; SEM, C, H; Jurkat, D, I; CEM, E, J) in regular media supplemented with hypoxanthine or DMSO control. Leukemia cell viability was assessed after 48 hours of drug treatment using the CellTiter-Glo Luminescent Cell Viability Assay. Error bars represent the mean ± SD of three technical replicates.
