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. 2024 Jul 19;14:1440650. doi: 10.3389/fonc.2024.1440650

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Copyright © 2024 Wang, Ostergaard, Kang, Sagong, Twite, Vargas-Morales and Gordon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypoxanthine concentrations required to rescue thiopurine toxicity. Hypoxanthine dose-response curves for leukemia cells (NALM-6, A, F; REH, B, G; SEM, C, H; Jurkat, D, I; CEM, E, J) in the presence of 6-MP 4.7 μM (A–E) or 6-TG 4.7 μM (F–J). Leukemia cell viability was assessed after 48 hours of drug treatment using the CellTiter-Glo Luminescent Cell Viability Assay. Error bars represent the mean ± SD of three technical replicates. EC50 values with confidence intervals were calculated from the dose-response curves and are shown for each cell line.