Figure 1.

Isolation and primary characterization of the iC series of SARS-CoV-2 binding antibodies. Nucleotide sequences encoding iC1-5 antibodies were obtained from single-sorted B cells of a previously vaccinated COVID-19 convalescent individual using single cell PCR (A). The iC antibodies underwent more intensive somatic hypermutation (SHM) compared to the iB antibodies (18) (**** – p<0.0001) (B). BLI analysis of the binding affinity between iC1 and SARS-CoV-2 RBD variants shows picomolar to nanomolar values (C). In vitro pseudovirus neutralization by the iC1 antibody demonstrates its broad neutralizing activity (D, E).