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. 2024 Jul 19;15:1442160. doi: 10.3389/fimmu.2024.1442160

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Copyright © 2024 Guselnikov, Baranov, Kulemzin, Belovezhets, Chikaev, Murasheva, Volkova, Mechetina, Najakshin, Chikaev, Solodkov, Sergeeva, Smirnov, Serova, Serov, Markhaev, Kononova, Alekseev, Gulyaeva, Danilenko, Battulin, Shestopalov and Taranin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epitope mapping of iC1 binding to the RBD of SARS-CoV-2. Neutralizing activity on a panel of 15 pseudoviruses with the Spike protein (Wuhan-1) variant carrying single amino acid substitutions in the RBD region (A). A 3D model of the RBD (SARS-CoV-2) with highlighted substitutions causing effect on iC1 neutralizing activity (yellow/blue) (B). BLI analysis of iC1 competition with 12 reference antibodies with known epitope structures. Negative values (dark blue color) mean that there is a competition, positive values (white/light blue color) means that there is no competition (C). An overlay of the epitopes for the reference antibodies with single amino acid residues influencing the iC1 neutralizing activity (D).