Table 3.

Randomized control trials with administration of MP to post-menopausal women. Suggested doses, administration routes, regimens and side effects of MP and placebo [once a day (q.d.)]. Side effects did not differ between MP and placebo administration, while they were not severe

Reference (participants in MP)	Aim	Regimen and administration route	Side effects of MP	Side effects of placebo	Primary outcome
Hitchcock et al., 2012 [166] (75)	Efficacy of MP regimen	300 mg MP q.d. per os at bedtime	Abdominal sensation, depression, anxiety, dizziness, breast lump, daytime drowsiness, dry mouth, facial swelling, rash, vasomotor symptoms, nausea, insomnia, mastalgia, multiday menstrual bleeding.	Insomnia, leg pain, initial daytime drowsiness, weight gain.	Vasomotor symptoms
Prior et al., 2012 [167] (75)	Efficacy of MP regimen	300 mg MP q.d. per os at bedtime	No serious side effects	No serious side effects	Vasomotor symptoms, withdrawal effects
Schüssler et al., 2008 [172] (10)	Efficacy of MP regimen	300 mg MP q.d. per os in the evening x 21d	Non reported	Non reported	Sleep quality, cognition