Table 1.

Anticonvulsant potencies of levetiracetam, brivaracetam, gabapentin and pregabalin in the commonly used acute experimental seizure models in mice

ASM \ Model	MES	PTZ	6 Hz (32 mA)	6 Hz (44 mA)
Levetiracetam	N.A.	N.A.	14.42a	345.4b
Brivaracetam	113c	30c	4.4d	N.D.
Gabapentin	> 400f	199.3e	72.11a	N.D.
Pregabalin	130.3f	N.D.	31.66a	N.D.

Data are presented as median effective doses (ED50 values in mg/kg) of the ASMs. MES– maximal electroshock-induced generalized tonic seizures; PTZ– pentylenetetrazole-induced generalized clonic seizures; 6 Hz–6 Hz corneal stimulation-induced secondary generalized motor seizures; N.A.– not active; N.D.– not determined. a– results from [77]; b– results from [167]; c– results from [66]; d– results from [168]; e– results from [133]; f– results from [130]