Table 1.
TFs predicted to bind at the SNP sequences with p < 0.01
SNP | Name |
P-value (common allele) |
P-value (rare allele) |
p-value (combined) |
---|---|---|---|---|
rs10757278 | V$STAT_01 | 0.0080 | 0.077 | 0.0052 |
rs7859727 | V$GATA6_01 | < 0.00057 | 0.824 | 0.0041 |
Calculated with the Transcription factor Affinity Prediction (TRAP) Web Tool TRAP (multiple sequences), using the matrix file ‘transfac_2010.1 vertebrates’, the background model ‘human_promoters’ and 10 bp +/- the SNP alleles:
rs10757278: CATTCCGGTA[A/G]GCAGCGATGC,
rs7859727: ATCTGAATGA[T/C]AGGCATTCCT