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. 2024 Jun 15;34(7):1365–1375. doi: 10.4014/jmb.2404.04040

Table 1.

List of genes associated with the pathogenicity of C. auris.

Gene name Description Infection method Virulence Reference
HOG1 MAP kinase activity Systemic infection Strongly attenuated [65]
PMR1 Involved in cell wall mannosylation Systemic infection Weakly attenuated [66]
VAN1 Involved in cell wall mannosylation Systemic infection Weakly attenuated [66]
DINOR Modulating genome integrity, cell filamentation Systemic infection Strongly attenuated [28]
BCY1 Protein kinase A regulatory subunit Systemic infection Weakly attenuated [64]
ELM1 Involved in the regulation of cell morphology Systemic infection Strongly attenuated [30]
PDE2 Involved negative regulation of cAMP-mediated RAS signaling Systemic infection Moderately attenuated [63]
SAPA3 Primary aspartic-type endopeptidase Systemic infection Moderately attenuated [67]
SCF1 Adhesin specifically required for adhesion in C. auris Systemic and skin infection Strongly attenuated [68]