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. 2024 May 30;34(7):1433–1442. doi: 10.4014/jmb.2401.01027

Fig. 5. MBNL3 modulated AKT/VEGFA pathway to aggravate GAC progression.

Fig. 5

(A) The protein expressions of p-PI3K, PI3K, p-AKT, AKT, VEGFA were tested through western blot in AGS cells. Groups were divided into the sh-NC, sh- MBNL3 and sh-MBNL3+740 Y-P group. (B) The protein expressions of p-PI3K, PI3K, p-AKT, AKT, VEGFA were tested through western blot in MKN45 cells. Groups were divided into the vector, MBNL3, and MBNL3+LY294002 group. (C) The cell proliferation was assessed through CCK-8 assay. Groups were divided into the sh-NC, sh-MBNL3 and sh-MBNL3+740 YP group. (D) The cell invasion was examined through Transwell assay. Groups were divided into the sh-NC, sh-MBNL3 and sh- MBNL3+740 Y-P group. (E) The angiogenic ability was evaluated through tube formation assay. Groups were divided into the sh-NC, sh-MBNL3 and sh-MBNL3+740 Y-P group. ***p < 0.001 vs the sh-NC group; ##p < 0.01, ###p < 0.001 vs the sh- MBNL3 group.