Figure 2.

Response of MTSs to variation in load magnitude or load duration

(A–F) ES-histograms for 1,000 simulated populations of MTSs subject to a (A, C, and E) load magnitude ($F$) drawn from a uniform distribution between 0 and 10 pN and a characteristic load duration ($\tau$) of 1 s, or (B, D, and F) $F$ of 5 pN and $\tau$ drawn from a log-uniform distribution from 10^−0.5 to 10^0.5 s for cases of (A and B) no FP mechanical switching, (C and D) acceptor mechanical switching only, or (E and F) donor mechanical switching only, according to base model parameters given in Note S1 and Table S2. Each MTS population comprises 50 sensors having the same FP parameters, $F$ values, and $\tau$ values. The color bars indicate bin counts. In all plots, reference black lines are tension isoclines for acceptor-only or donor-only mechanical switching at $F$ of 0, 3, and 6 pN (from right to left).

See also Note S1 and Figures S5–S12.