TABLE 1.
Sequence variations among MelARV, Emv-2, and Emv-11 viruses in all regions
| Genome region and nucleotide positiona | Emv-11 (AKR) | MelARV (B16) | Emv-2 (C57B/6) | ||
|---|---|---|---|---|---|
| 5′UTRb | |||||
| 129 | C | C | T | ||
| 263-4 | TG | Deleted | Deleted | ||
| 333 | C | T | T | ||
| 433 | G | A | G | ||
| 468 | T (inserted) | ||||
| 598 | C | T | T | ||
| Gag-p15 | |||||
| 646 | A (Gln) | A (Gln) | A (Gln) | ||
| 809 | T | T | C | ||
| 929 | C | A | C | ||
| 1009 | C (Pro) | T (Leu) | C (Pro) | ||
| Gag-p12 | |||||
| 1144 | T (Leu) | C (Pro) | C (Pro) | ||
| Gag-p30 | |||||
| 1285 | T (Leu) | C (Pro) | T (Leu) | ||
| 1376 | G | A | G | ||
| 1389 | C | T | C | ||
| 1394 | T | C | T | ||
| 1397 | A | C | A | ||
| 1406 | A | G | A | ||
| 1409 | C | T | T | ||
| 1434 | T (Trp) | C (Arg) | T (Trp) | ||
| 1439 | T | C | T | ||
| 1442 | T | C | T | ||
| 1445 | C | T | C | ||
| 1454 | A | G | A | ||
| 1457 | A | G | A | ||
| 1469 | T | G | T | ||
| 1472 | C | A | C | ||
| 1475 | G | A | G | ||
| 1478 | G | A | G | ||
| 1481 | G | A | G | ||
| 1499 | G | A | G | ||
| 1502 | A | G | A | ||
| 1506 | C | A | C | ||
| 1511 | G | G | A | ||
| 1514 | T | A | T | ||
| 1532 | G | A | G | ||
| 1544-5 | AC | GT | AC | ||
| 1550 | C | T | C | ||
| 1553 | C | T | C | ||
| 1556 | G | A | G | ||
| 1559-60 | TG (Asp) | CA (Asn) | TG (Asp) | ||
| 1562-63 | CG (Ala) | TT (Ser) | CG (Ala) | ||
| 1565 | T | C | T | ||
| 1568 | T | C | T | ||
| 1571 | T | C | T | ||
| 1598 | C | T | C | ||
| 1601 | C | A | C | ||
| 1606-9 | AAAG (GlnArg) | CTGA (ProGlu) | AAAG (GlnArg) | ||
| 1646 | T | C | T | ||
| 1652 | A | A | G | ||
| 1719 | A (Asn) | A (Asn) | G (Asp) | ||
| 1727 | C | T | C | ||
| 1884 | A (Ser) | G (Gly) | A (Ser) | ||
| 1970 | A | G | G | ||
| 2024 | G | A | G | ||
| Gag-p10 | |||||
| 2109 | G (Gly) | A (Arg) | G (Gly) | ||
| 2119 | G (Arg) | T (Met) | G (Arg) | ||
| Pol | |||||
| 2375 | G | C | C | ||
| Genome region and nucleotide positiona | Emv-11 (AKR) | MelARV (B16) | Emv-2 (C57B/6) | ||
| 2504 | C | T | C | ||
| 2538 | C | T | C | ||
| 2643 | T (Tyr) | C (His) | C (His) | ||
| 2668 | T (Val) | C (Ala) | C (Ala) | ||
| 2690 | C | T | T | ||
| 2824 | A (Lys) | G (Arg) | G (Arg) | ||
| 2978 | G | G | A | ||
| 3129 | A (Arg) | G (Gly) | A (Arg) | ||
| 3161 | A | G | A | ||
| 3219 | C | T | C | ||
| 3221 | A | G | A | ||
| 3288 | A (Ile) | T (Leu) | A (Ile) | ||
| 3298 | A | G | A | ||
| 3302 | C | T | C | ||
| 3308 | T | C | T | ||
| 3311 | G | A | G | ||
| 3314 | C | A | C | ||
| 3341-2 | GT | TC | GT | ||
| 3346 | T (Leu) | A (Gln) | T (Leu) | ||
| 3356 | A | G | A | ||
| 3365 | G | A | G | ||
| 3368 | T | C | T | ||
| 3393 | C (Leu) | A (Ile) | C (Leu) | ||
| 3395 | T | C | T | ||
| 3410 | C | T | C | ||
| 3413 | G | A | G | ||
| 3416 | T | C | C | ||
| 3425 | T | C | T | ||
| 3428 | C | T | C | ||
| 3431 | A | G | A | ||
| 3433-4 | AA (Lys) | GG (Arg) | AA (Lys) | ||
| 3461 | C | T | C | ||
| 3485 | G | A | G | ||
| 3488-90 | TAC (Thr) | CGT (Val) | TAC (Thr) | ||
| 3494 | G | A | G | ||
| 3500 | C | T | C | ||
| 3542 | T | C | T | ||
| 3575 | A | G | A | ||
| 3576 | G (Ala) | G (Ala) | C (Pro) | ||
| 3614 | C | T | C | ||
| 3665 | C | T | C | ||
| 3785 | C | T | C | ||
| 3812 | T | C | C | ||
| 3824 | T | C | T | ||
| 3839 | T | C | T | ||
| 3966 | C (Leu) | A (Ile) | C (Leu) | ||
| 4005 | C (Leu) | A (Ile) | C (Leu) | ||
| 4070 | C | A | C | ||
| 4077 | G (Glu) | A (Lys) | G (Glu) | ||
| 4172 | C | T | C | ||
| 4223 | G | T | G | ||
| 4549 | C (Ser) | A (Thr) | C (Ser) | ||
| 4583 | G | A | G | ||
| 4983 | T (Ser) | A (Thr) | T (Ser) | ||
| 5185 | C (Pro) | C (Pro) | T (Leu) | ||
| 5336 | T | G | T | ||
| 5375 | T | C | T | ||
| 5409 | C | T | T | ||
| 5453 | T | C | C | ||
| 5575 | A (Gln) | G (Arg) | G (Arg) | ||
| 5597 | A | G | A | ||
| 5765 | G | A | G | ||
| Env-gp70 | |||||
| 5879 | A (Thr) | G (Ala) | G (Ala) | ||
| 5915 | A (Thr) | T (Ser) | T (Ser) | ||
| 6116 | C (Pro) | T (Ser) | C (Pro) | ||
| 6184 | C | C | C | ||
| 6214 | A | C | C | ||
| 6222 | G (Gly) | A (Glu) | G (Gly) | ||
| 6224 | G (Gly) | G (Gly) | A (Arg) | ||
| 6271 | A | G | G | ||
| 6349 | G | G | C | ||
| 6419 | G (Glu) | A (Lys) | G (Glu) | ||
| 7057 | T | C | C | ||
| Env-p15E | |||||
| 7475 | T (Phe) | C (Leu) | T (Phe) | ||
| 7769-70 | GA (Glu) | GG (Gly) | GA (Glu) | ||
| 3′UTR | |||||
| 7875 | T | C | C | ||
| 8006 | C | C | C | ||
| 8012 | C | C | C | ||
| 8014 | A (inserted) | ||||
| 8035-134 | Deleted | Deleted | |||
| 8298 | G | A | A |
a
The nucleotide positions are numbered in accordance with the system used by Herr in the nucleotide sequence of the AKV-623 provirus (12). Changes in deduced amino acid sequences are noted in brackets following the corresponding nucleotides.
b
UTR, untranslated region.