Table 4.
analysis of Figure 3 Pharmacology
| Table 4A Nicotine peak currents | |||||
|---|---|---|---|---|---|
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| α7 peak, α7(α9α10)2 peak, α7(α9α10)3 peak, α7(α9α10)4 peak, α9α10 peak | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 33 | 47.725917 | 1.4462399 | ||
| A | 4 | 31.079279 | 7.7698197 | 13.535752 | < .0001 |
| Error | 29 | 16.646639 | 0.57402202 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| α7 peak vs α7(α9α10)2 peak | 0.977414 | 2.4135 | 0.2234 | −0.25293 to 2.2078 |
| α7 peak vs α7(α9α10)3 peak | 1.69071 | 4.1748 | 0.0025 | 0.46037 to 2.921 |
| α7 peak vs α7(α9α10)4 peak | 2.51034 | 6.1987 | < .0001 | 1.28 to 3.7407 |
| α7 peak vs α7(α9α10)2 peak | 2.50163 | 5.9349 | < .0001 | 1.2211 to 3.7822 |
| α7(α9α10)2 peak vs α7(α9α10)3 peak | 0.713293 | 1.7613 | 0.8873 | −0.51705 to 1.9436 |
| α7(α9α10)2 peak vs α7(α9α10)4 peak | 1.53292 | 3.7852 | 0.0071 | 0.30258 to 2.7633 |
| α7(α9α10)2 peak vs α9α10 peak | 1.52421 | 3.6161 | 0.0112 | 0.24364 to 2.8048 |
| α7(α9α10)3 peak vs α7(α9α10)4 peak | 0.819629 | 2.0239 | 0.5228 | −0.41071 to 2.05 |
| α7(α9α10)3 peak vs α9α10 peak | 0.810921 | 1.9238 | 0.6424 | −0.46966 to 2.0915 |
| α7(α9α10)4 peak vs α9α10 peak | −0.00870844 | 0.0207 | 1 | −1.2893 to 1.2719 |
| Nicotine Net charge | |||||
|---|---|---|---|---|---|
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| α7 charge, α7(α9α10)2 charge, a7(a9a10)3 charge, a7(a9a10) 4 charge, a9a10 charge | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 33 | 6.6619212 | 0.2018764 | ||
| A | 4 | 6.2062219 | 1.5515555 | 98.738614 | < .0001 |
| Error | 29 | 0.45569922 | 0.015713766 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| α7 charge vs α7(α9α10)2 charge | 0.371516 | 5.5446 | < .0001 | 0.16795 to 0.57508 |
| α7 charge vs α7(α9α10)3 charge | 0.844269 | 12.6001 | < .0001 | 0.64071 to 1.0478 |
| α7 charge vs α7(α9α10)4 charge | 1.08297 | 16.1626 | < .0001 | 0.87941 to 1.2865 |
| α7 charge vs α9α10 charge | 1.08529 | 15.5618 | < .0001 | 0.87341 to 1.2972 |
| α7(α9α10)2 vs α7(α9α10)3 charge | 0.472753 | 7.0555 | < .0001 | 0.26919 to 0.67632 |
| α7(α9α10)2 vs α7(α9α10)4 charge | 0.711454 | 10.6179 | < .0001 | 0.50789 to 0.91502 |
| α7(α9α10)2 charge vs α9α10 charge | 0.713775 | 10.2347 | < .0001 | 0.5019 to 0.92565 |
| α7(α9α10)3 vs α7(α9α10)4 charge | 0.2387 | 3.5624 | 0.0129 | 0.035136 to 0.44226 |
| α7(α9α10)3 vs α9α10 charge | 0.241021 | 3.456 | 0.0171 | 0.029145 to 0.4529 |
| α7(α9α10)4 vs α9α10 charge | 0.00232117 | 0.0333 | 1 | −0.20955 to 0.2142 |
| Table 4B pCN-diEPP peak currents | |||||
|---|---|---|---|---|---|
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| α7 peak, α7(α9α10)2 peak, α7(α9α10)3 peak, α7(α9α10)4 peak, α9α10 peak | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 34 | 25.446475 | 0.74842572 | ||
| A | 4 | 18.238626 | 4.5596566 | 18.977882 | < .0001 |
| Error | 30 | 7.2078483 | 0.24026161 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| a7 peak vs α7(α9α10)2 peak | −0.0109723 | 0.0419 | 1 | −0.80479 to 0.78285 |
| a7 peak vs a7(a9a10)3 peak | −0.917661 | 3.5025 | 0.0147 | −1.7115 to −0.12384 |
| a7 peak vs a7(a9a10)4 peak | −1.83001 | 6.9847 | < .0001 | −2.6238 to −1.0362 |
| a7 peak vs a9a10 peak | −1.31903 | 5.0344 | 0.0002 | −2.1129 to −0.52522 |
| α7(α9α10)2 peak vs a7(a9a10) 3 peak | −0.906689 | 3.4606 | 0.0164 | −1.7005 to −0.11287 |
| α7(α9α10)2 peak vs a7(a9a10) 4 peak | −1.81904 | 6.9428 | < .0001 | −2.6129 to −1.0252 |
| α7(α9α10)2 peak vs a9a10 peak | −1.30806 | 4.9925 | 0.0002 | −2.1019 to −0.51424 |
| a7(a9a10)3 peak vs a7(a9a10)4 peak | −0.912348 | 3.4822 | 0.0155 | −1.7062 to −0.11853 |
| a7(a9a10)3 peak vs a9a10 peak | −0.401373 | 1.5319 | 1 | −1.1952 to 0.39245 |
| a7(a9a10)4 peak vs a9a10 peak | 0.510974 | 1.9503 | 0.6054 | −0.28285 to 1.3048 |
| pCN-diEPP Net Charge | |||||
|---|---|---|---|---|---|
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| a7 charge, α7(α9α10)2 charge, a7(a9a10)3 charge, a7(a9a10)4 charge, a9a10 charge | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 34 | 9.0405759 | 0.26589929 | ||
| A | 4 | 7.8405214 | 1.9601304 | 49.001034 | < .0001 |
| Error | 30 | 1.2000545 | 0.040001816 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| α7 charge vs α7(α9α10)2 charge | 0.008322 | 0.0778 | 1 | −0.31558 to 0.33223 |
| α7 charge vs α7(α9α10)3 ch. | −0.878618 | 8.2185 | < .0001 | −1.2025 to −0.55471 |
| α7 charge vs α7(α9α10)4 ch. | −0.875816 | 8.1923 | < .0001 | −1.1997 to −0.55191 |
| α7 charge vs α9α10 charge | −1.09152 | 10.21 | < .0001 | −1.4154 to −0.76761 |
| α7(α9α10)2 charge vs α7(α9α10)3 ch. | −0.88694 | 8.2964 | < .0001 | −1.2108 to −0.56303 |
| α7(α9α10)2 charge vs α7(α9α10)4 ch. | −0.884138 | 8.2702 | < .0001 | −1.208 to −0.56023 |
| α7(α9α10)2 charge vs α9α10 charge | −1.09984 | 10.2878 | < .0001 | −1.4237 to −0.77593 |
| α7(α9α10)3 ch. vs α7(α9α10)4 char | 0.00280213 | 0.0262 | 1 | −0.3211 to 0.32671 |
| α7(α9α10)3 ch. vs α9α10 charge | −0.2129 | 1.9914 | 0.556 | −0.53681 to 0.11101 |
| α7(α9α10)4 ch. vs α9α10 charge | −0.215702 | 2.0177 | 0.5265 | −0.53961 to 0.1082 |
| Table 4C Inhibition of ACh responses by mCN-diEPP | |||||
|---|---|---|---|---|---|
| Peak currents | |||||
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| a7 peak, α7(α9α10)2 peak, a7(a9a10) 3 peak, a7(a9a10) 4 peak, a9a10 peak | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 32 | 1.9254888 | 0.060171524 | ||
| A | 4 | 1.3377141 | 0.33442853 | 15.931274 | < .0001 |
| Error | 28 | 0.58777464 | 0.020991952 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| α7 peak vs α7(α9α10)2 peak | 0.156714 | 1.9442 | 0.6199 | −0.08889 to 0.40232 |
| α7 peak vs α7(α9α10)3 peak | 0.126972 | 1.5752 | 1 | −0.11863 to 0.37258 |
| α7 peak vs α7(α9α10)4 peak | −0.162472 | 2.0156 | 0.5353 | −0.40808 to 0.083132 |
| α7 peak vs α9α10 peak | 0.458369 | 5.4796 | < .0001 | 0.20349 to 0.71324 |
| α7(α9α10)2 peak vs α7(α9α10)3 peak | −0.0297416 | 0.384 | 1 | −0.26571 to 0.20623 |
| α7(α9α10)2 peak vs α7(α9α10)4 peak | −0.319186 | 4.1215 | 0.003 | −0.55515 to −0.083217 |
| α7(α9α10)2 peak vs α9α10 peak | 0.301655 | 3.7423 | 0.0083 | 0.056051 to 0.54726 |
| α7(α9α10)3 peak vs α7(α9α10)4 peak | −0.289445 | 3.7374 | 0.0085 | −0.52541 to −0.053476 |
| α7(α9α10)3 peak vs α9α10 peak | 0.331396 | 4.1113 | 0.0031 | 0.085792 to 0.577 |
| α7(α9α10)4 peak vs α9α10 peak | 0.620841 | 7.7021 | < .0001 | 0.37524 to 0.86645 |
| Net Charge | |||||
|---|---|---|---|---|---|
| One Way ANOVA | |||||
| Data Table: Data with three ratios | |||||
| Factor A: 5 Groups | |||||
| a7 charge, α7(α9α10)2 charge, a7(a9a10)3 charge, a7(a9a10) 4 charge, a9a10 charge | |||||
| Analysis of Variance Results | |||||
| Source | DF | SS | MS | F | P |
| Total | 32 | 1.9115891 | 0.05973716 | ||
| A | 4 | 1.526624 | 0.381656 | 27.759314 | < .0001 |
| Error | 28 | 0.38496513 | 0.013748755 | ||
| Bonferroni’s All Pairs Comparison | ||||
|---|---|---|---|---|
| Comparison | Mean Difference | |t| | P | 95% CL |
| α7 charge vs α7(α9α10)2 charge | 0.0839687 | 1.2872 | 1 | −0.1148 to 0.28273 |
| α7 charge vs α7(α9α10)3 charge | −0.198647 | 3.0451 | 0.0502 | −0.39741 to 0.00011879 |
| α7 charge vs α7(α9α10)4 charge | −0.114133 | 1.7496 | 0.9114 | −0.3129 to 0.084632 |
| α7 charge vs α9α10 charge | 0.436095 | 6.4418 | <.0001 | 0.22983 to 0.64236 |
| α7(α9α10)2 charge vs α7(α9α10)3 ch. | −0.282615 | 4.5092 | 0.0011 | −0.47358 to −0.091648 |
| α7(α9α10)2 charge vs α7(α9α10)4 char | −0.198102 | 3.1608 | 0.0376 | −0.38907 to −0.0071345 |
| α7(α9α10)2 charge vs α9α10 charge | 0.352126 | 5.3978 | < .0001 | 0.15336 to 0.55089 |
| α7(α9α10)3 ch vs α7(α9α10)4 char | 0.0845132 | 1.3484 | 1 | −0.10645 to 0.27548 |
| α7(α9α10)3 ch vs α9α10 charge | 0.634742 | 9.7301 | <.0001 | 0.43598 to 0.83351 |
| α7(α9α10)4 char vs α9α10 charge | 0.550228 | 8.4346 | <.0001 | 0.35146 to 0.74899 |