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. 2024 Aug 2;12:76. doi: 10.1186/s40364-024-00612-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification and characteristics of the monocyte-macrophage lineage in intestinal mucosa from IBD patients. (A, C) UMAP plots defines 8 clusters in CD (A) and UC (C) patients, respectively. (B, D) Dot plots showing expression levels of selected signature genes of the monocyte-macrophage lineage subsets in intestinal mucosa from CD (B) and UC (D) patients. Dot size indicates fraction of expressing cells, colored based on the relative expression of specific gene. (E, F) The developmental trajectory of the monocyte-macrophage lineage subsets in CD patients (E) and UC patients (F) inferred by Monocle2