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Macrophages modulate mesentery immune homeostasis in IBD patients. The development of creeping fat, mesenteric fibrosis as well as lymphatic vessel obstruction in the mesentery are reckoned as the characteristics of IBD patients. Macrophages infiltrate in the mesentery and involve in the modulation of extraintestinal immune homeostasis in IBD patients via macrophage-associated genes including SAA2 and ARG2, which are highly expressed in the mesentery and intestinal mucosa
