TABLE 3.
Linkage of lymphoma incidence in backcross micea
| Locus | cM | LOD | Lymphoma-positive mice (progressors)
|
Normal mice (LTNP)
|
χ2 | P | ||
|---|---|---|---|---|---|---|---|---|
| c/c | b/c | c/c | b/c | |||||
| D15Mit187 | 44 | 1.8 | 15 | 5 | 6 | 14 | 8.1 | 0.004 |
| D15Mit28 | 44 | 1.8 | 15 | 5 | 6 | 14 | 8.1 | 0.004 |
| D15Mit68 | 46 | 1.8 | 15 | 5 | 6 | 14 | 8.1 | 0.004 |
| D15Mit32 | 48 | 2.3 | 15 | 5 | 5 | 15 | 9.1 | 0.003 |
| D15Mit159 | 52 | 2.3 | 15 | 5 | 5 | 15 | 9.1 | 0.003 |
| D15Mit77 | 56 | 2.8 | 15 | 5 | 4 | 16 | 12.1 | 0.0005b |
| D15Mit79 | 66 | 1.9 | 14 | 5 | 5 | 14 | 8.1 | 0.004 |
a
Numbers of mice with or without evidence of lymphoma are given, grouped by their genotypes at the indicated locus. Mice were genotyped as c/c or b/c depending on whether the alleles detected at the indicated locus (e.g., D15Mit187) were derived from BALB.K (c) or B10.BR (b). χ2 and P values were derived from a 2-by-2 contingency test.
b
Suggestive linkage of marker to lymphoma incidence; not significant.