Table 2.
Meta-analysis of the association between KIR genes and susceptibility to ulcerative colitis.
| Gene | Qualified studies | Cases (n/N) | Controls (n/N) | OR (95 % CI) | z- test | P | pc |
Publication bias |
Heterogeneity |
Effect model | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E L R | B& M T | PQ | I2 | |||||||||
| KIR2DL1 | 6 | 581/622 | 1453/1485 | 0.501 (0.302–0.832) | −2.672 | 0.131 | 1.000 | 0.851 | 0.550 | 0.167 | 38.20 | FEM |
| KIR2DL2 | 6 | 263/622 | 690/1485 | 0.937 (0.600–1.464) | −0.285 | 0.776 | 1.000 | 0.851 | 0.866 | 0.002 | 73.28 | REM |
| KIR2DL3 | 6 | 524/622 | 1352/1485 | 0.530 (0.317 to 0.886) | −2.420 | 0.015 | 0.540 | 0.851 | 0.490 | 0.036 | 58.08 | REM |
| KIR2DL5 | 6 | 310/622 | 750/1485 | 1.101 (0.803–1.510) | 0.598 | 0.550 | 1.000 | 0.573 | 0.447 | 0.056 | 53.55 | REM |
| KIR2DS1 | 5 | 246/522 | 583/1379 | 1.243 (1.002 to 1.543) | 1.976 | 0.048 | 1.000 | 0.327 | 0.108 | 0.170 | 37.70 | FEM |
| KIR2DS2 | 5 | 258/522 | 656/1379 | 1.131 (0.904–1.417) | 1.077 | 0.281 | 1.000 | 1.000 | 0.646 | 0.231 | 28.54 | FEM |
| KIR2DS3 | 5 | 171/522 | 397/1379 | 1.279 (1.016 to 1.610) | 2.099 | 0.036 | 1.000 | 0.624 | 0.444 | 0.156 | 39.77 | FEM |
| KIR2DS4 | 3 | 364/395 | 746/791 | 0.675 (0.325–1.401) | −1.055 | 0.291 | 1.000 | 0.602 | 0.531 | 0.096 | 57.28 | REM |
| KIR2DS4full | 2 | 45/127 | 386/588 | 0.554 (0.324 to 0.947) | −2.161 | 0.031 | 1.000 | - | - | 0.544 | 0.00 | FEM |
| KIR2DS5 | 4 | 141/411 | 343/1129 | 1.313 (0.764–2.257) | 0.985 | 0.324 | 1.000 | 0.497 | 0.333 | 0.006 | 75.75 | REM |
| KIR3DL1 | 6 | 588/622 | 1414/1485 | 0.847 (0.550–1.303) | −0.758 | 0.449 | 1.000 | 0.573 | 0.371 | 0.657 | 0.00 | FEM |
| KIR3DS1 | 5 | 236/522 | 577/1379 | 1.151 (0.931–1.422) | 1.299 | 0.194 | 1.000 | 0.327 | 0.243 | 0.235 | 27.93 | FEM |
KIR: Killer Immunoglobulin-like Receptor; OR: Odds Ratio; 95 % CI: 95 % Confidence Interval; FEM: Fixed-Effect Model; REM: Random-Effect Model; n/N: number of carriers a certain KIR/total; B & M T: Begg and Mazumdar test; E L R: Egger's linear regression.