Table 2.

Potential side effects of SGLT2 inhibitors

Side effect	High-risk population
Genitourinary infections, including urinary tract infection, candida infections and rare cases of Fournier's gangrene	Patients with known risk factors for genitourinary infections including concomitant immunosuppression
Diabetic ketoacidosis	Any history of diabetic ketoacidosis
Hypotension/volume depletion	Concomitant use of blood pressure medications and/or diuretics Population at risk for being unable to drink sufficient fluids
Fragility fractures	Any other risk factors for osteoporosis including high dose steroid use
Lower limb amputation	Avoid use in patients with severe neuropathy, peripheral vascular disease or foot ulcerations which carry higher risks for amputation