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. 2024 Aug 2;10(31):eadn7979. doi: 10.1126/sciadv.adn7979

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Fig. 1. — (A) S. pyogenes HSC5 cells treated under both sublethal (0.4 μM) and bactericidal (20 μM) concentrations of PS757 exhibited nucleoid abnormality with altered nucleoid structure that was less dense and very filamentous (white arrows). S. pyogenes HSC5 cells treated under bactericidal (20 μM) concentration of PS757 were observed with small dense globular structures at periphery of bacterial cell wall (red arrows), suggesting that PS757 produced cell wall abnormalities. (B) S. pyogenes HSC5 cells treated under bactericidal (20 μM) concentration of PS757 were observed with irregular and heterogeneous cell wall structures, indicating that PS757 induced cell wall damages. DMSO, dimethyl sulfoxide.