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. 2024 Aug 2;10(31):eadn7979. doi: 10.1126/sciadv.adn7979

Fig. 4. GmPcide PS757 treatment promoted ulcer healing and bacterial clearance in S. pyogenes SSTI in mice.

Fig. 4.

(A) Timeline of the 12-day infection and treatment protocol by using PS757 to treat S. pyogenes SSTI in mice. (B and C) PS757 treatment promoted ulcer healing in S. pyogenes SSTI in mice during 12 days of infection (P < 0.001). (D) PS757-treated mice were observed with quicker eschars slough-off from the infected skin than the untreated group in 12-day S. pyogenes SSTI in mice. (E) PS757 treatment promoted the clearance of bacterial infection at day 12 in S. pyogenes SSTI in mice (P < 0.0001). Statistics were performed with Mann-Whitney U test. P ≤ 0.05 is considered as statistically significant. ***P < 0.001 and ****P < 0.0001.