Table 4. Association of rs5810761 genotypes on muscle function and body composition.

All participants n = 134

-9-9

-9+9

+9+9

P value

6MWD

308 (250–376)

324 (259–377)

293 (199–380)

0.506

6MWD improvement 12m, m

23 (-21-57)

2 (-29.5–55.8)

27 (-38.0–50.0)

0.318

SPPB

7.0 (6.0–9.0)

7.0 (6.0–9.0)

7.0 (5.0–9.0)

0.533

SPPB improvement 12m

0.0 (1.0–1.0)

0.0 (-1.0–1.3)

1.0 (1.0–2.0)

<0.001

Chair-stand time, sec

20.4 (15.0–26.3)

21.9 (14.9–27.9)

23.3 (19.2–29.6)

0.192

Gait speed, m/s

5.0 (4.2–6.1)

5.3 (4.5–6.7)

5.1 (4.3–8.3)

0.350

Grip strength improvement 12m, kg

1.2 (-2.1–3.1)

-0.60 (-1.70–5.22)

1.1 (-0.55–3.8)

0.098

By gender:

Male n = 63

Female n = 71

-9-9

-9+9

+9+9

P

-9-9

-9+9

+9+9

P

Grip strength, kg

23.6 (19.0–27.6)

23.5 (20.3–26.9)

22.2 (16.2–25.6)

0.397

12.4 (10.7–16.8)

14.1 (11.3–16.6)

12.6 (9.9–16.7)

0.725

6MWD, m

321 (219–378)

354 (280–414)

310 (148–400)

0.327

308 (256–378)

300 (231–353)

283 (248–360)

0.779

QMVC, kg

15.2 (10.1–16.8)

14.5 (12.1–21.4)

18.0 (12.5–21.0)

0.552

9.5 (6.4–12.7)

9.0 (6.7–13.2)

10.2 (7.0–12.4)

0.901

Arm fat mass, kg

2.39 (1.33–2.62)

2.72 (2.05–3.33)

2.76 (2.33–3.41)

0.019

3.15 (2.84–3.52)

3.19 (2.31–3.83)

2.89 (2.41–4.41)

0.876

Leg fat mass, kg

6.40 (4.93–8.47)

6.48 (5.87–8.84)

7.12 (5.70–8.82)

0.582

9.53 (8.22–11.78)

9.91 (7.85–12.58)

8.39 (7.02–11.31)

0.334

Arm muscle mass, kg

5.34 (5.11–6.05)

6.19 (5.37–6.58)

5.71 (5.10–6.73)

0.117

3.39 (3.02–3.83)

3.29 (2.92–3.83)

3.42 (3.04–3.80)

0.664

Leg muscle mass, kg

15.6 (13.2–17.3)

15.8 (13.2–17.3)

15.1 (13.4–18.3)

0.634

11.1 (9.22–11.9)

10.5 (9.24–11.9)

10.6 (10.1–11.5)

0.852

6MWD six-minute walk distance; QMVC quadricep maximal voluntary contraction