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. 2024 Aug 2;15:6510. doi: 10.1038/s41467-024-50875-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — A Nebula facilitates comparative analysis of independent studies based on OmicScope and EnrichmentScope outputs (provided as a Source Data file). B–H Figures generated using Nebula. B Bar plot depicting the count of whole (gray) and differentially regulated proteins/genes (colored) across various studies, as well as the combined count. C Dot plot showing the count of up-regulated and down-regulated entities. D Top 10 enriched pathways according to the KEGG database for all organs. Upset plots for (E) proteins and (F) enrichment terms, illustrating overlapping sizes among conditions. G Circular plot displaying all differentially regulated proteins and their shared relationships among evaluated groups (cyan links), along with shared enrichment terms among groups (black links). Each protein is annotated with its respective foldchange. H Circular plot depicting proteins differentially regulated in Oxidative phosphorylation among studies, with accompanying foldchange values. Source data are provided as a Source Data file.