Fig. 3. Epigenetic age accelerations measured by different clocks.

A Differences in epigenetic age accelerations in different CD8⁺ subsets generated in this study. Horvath clock predictions overlaid in light gray. B Epigenetic ages of CD8⁺ naive cells and effector memory cells, based on data from GSE66564 and GSE83156. C Epigenetic ages of CD4⁺ naive cells and central memory cells, based on data from GSE121192 and GSE71825. D Epigenetic ages of PBMCs, CD8⁺ naive, CD8⁺ central memory, CD8⁺ combined effector and TEMRA, CD4⁺ naive, CD4⁺ central memory, B-cell naive, B-cell switched memory, CD16⁺CD56_dim NK, and classical monocyte cells. E–I Association of percentage of e, effector memory CD8⁺ cells, f, central memory CD4⁺ cells, g, class-switched B cells, h, CD16⁺ CD56_dim NK cells, and i, classical monocytes with epigenetic age acceleration. Samples derived from N = 9 individuals.