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. 2024 Aug 2;15:6534. doi: 10.1038/s41467-024-50877-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — A Experimental scheme for conditioned medium organoids with CTRL receiving media from HD and vice-versa. Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license B q-PCR for DLX2, DLX6, GAD1, MAP2, and TBR2 on CTRL and HD canonical (mono) and organoids conditioned from HD (condit HD) or from CTRL (condit CTRL) at DIV 120. (N = 4 pools of organoids from 2 independent biological replicates; error bars represent ± SEM; Anova One Way, Bonferroni post test, *p < 0,05; **p < 0,01) C CellChat circle plot communications between all subpopulations in each individual condition D CellChat bubble plot of gene expression for couples of ligands and receptors between cells grown together in the same organoid per each subpopulation. Abbreviations: VP=Ventral Progenitors; DP=Dorsal Progenitors; VN=Ventral Neurons; DN=Dorsal Neurons. Wilcoxon test, two-sided, Bonferroni adjustments for multiple comparisons E NeuronChat circle plot showing total communications between all subpopulations and conditions F NeuronChat stacked bar plot of gene expression for couples of ligands and receptors in each condition G Box plots of gene expression for GABRB3 receptor in ventral neurons and dorsal neurons for each condition. For G the box plots show the median (centre line), upper and lower quartiles (box limits), and the highest and lowest values within 1.5× the IQR of the nearest hinge (whiskers). Source data are provided as a Source Data file.