| 1 Maternal death |
3 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.1 Any antibiotic versus placebo |
3 |
763 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 1.2 All penicillin (excluding co‐amoxiclav) versus placebo |
1 |
85 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 1.3 Beta lactum (including co‐amoxiclav) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 1.4 Macrolide (including erythromycin) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 1.5 Other antibiotic versus placebo |
2 |
678 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2 Serious maternal morbidity |
0 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 2.1 Any antibiotic versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2.2 All penicillin (excluding co‐amoxiclav) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2.3 Beta lactum (including co‐amoxiclav) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2.4 Macrolide (including erythromycin) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 2.5 Other antibiotic versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 3 Perinatal death/death before discharge |
12 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 3.1 Any antibiotic versus placebo |
12 |
6301 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.76, 1.14] |
| 3.2 All penicillin (excluding co‐amoxiclav) versus placebo |
4 |
332 |
Risk Ratio (M‐H, Random, 95% CI) |
0.78 [0.31, 1.97] |
| 3.3 Beta lactum (including co‐amoxiclav) versus placebo |
2 |
1880 |
Risk Ratio (M‐H, Random, 95% CI) |
0.62 [0.15, 2.56] |
| 3.4 Macrolide (including erythromycin) versus placebo |
4 |
2138 |
Risk Ratio (M‐H, Random, 95% CI) |
0.83 [0.43, 1.60] |
| 3.5 Other antibiotic versus placebo |
3 |
762 |
Risk Ratio (M‐H, Random, 95% CI) |
1.13 [0.68, 1.88] |
| 4 Neonatal infection including pneumonia |
12 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 4.1 Any antibiotic versus placebo |
12 |
1680 |
Risk Ratio (M‐H, Random, 95% CI) |
0.67 [0.52, 0.85] |
| 4.2 All penicillin (excluding co‐amoxiclav) versus placebo |
5 |
521 |
Risk Ratio (M‐H, Random, 95% CI) |
0.30 [0.13, 0.68] |
| 4.3 Beta lactum (including co‐amoxiclav) versus placebo |
1 |
62 |
Risk Ratio (M‐H, Random, 95% CI) |
0.33 [0.01, 7.88] |
| 4.4 Macrolide (including erythromycin) versus placebo |
3 |
334 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.45, 1.37] |
| 4.5 Other antibiotic versus placebo |
3 |
763 |
Risk Ratio (M‐H, Random, 95% CI) |
0.71 [0.53, 0.95] |
| 5 Neonatal necrotising enterocolitis |
11 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 5.1 Any antibiotic versus placebo |
11 |
6229 |
Risk Ratio (M‐H, Random, 95% CI) |
1.09 [0.65, 1.83] |
| 5.2 All penicillin (excluding co‐amoxiclav) versus placebo |
3 |
262 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.25, 2.97] |
| 5.3 Beta lactum (including co‐amoxiclav) versus placebo |
2 |
1880 |
Risk Ratio (M‐H, Random, 95% CI) |
4.72 [1.57, 14.23] |
| 5.4 Macrolide (including erythromycin) versus placebo |
3 |
2076 |
Risk Ratio (M‐H, Random, 95% CI) |
0.88 [0.45, 1.69] |
| 5.5 Other antibiotic versus placebo |
4 |
823 |
Risk Ratio (M‐H, Random, 95% CI) |
0.89 [0.54, 1.47] |
| 6 Oxygen treatment > 36 weeks' postconceptual age |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 6.1 Any antibiotic versus placebo |
1 |
4809 |
Risk Ratio (M‐H, Random, 95% CI) |
0.91 [0.70, 1.17] |
| 6.2 All penicillin (excluding co‐amoxiclav) versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 6.3 Beta lactum (including co‐amoxiclav) versus placebo |
1 |
1818 |
Risk Ratio (M‐H, Random, 95% CI) |
0.92 [0.63, 1.36] |
| 6.4 Macrolide (including erythromycin) versus placebo |
1 |
1803 |
Risk Ratio (M‐H, Random, 95% CI) |
0.89 [0.61, 1.32] |
| 6.5 Other antibiotic versus placebo |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 7 Major cerebral abnormality on ultrasound before discharge |
12 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 7.1 Any antibiotic versus placebo |
12 |
6289 |
Risk Ratio (M‐H, Random, 95% CI) |
0.81 [0.68, 0.98] |
| 7.2 All penicillin (excluding co‐amoxiclav) versus placebo |
3 |
262 |
Risk Ratio (M‐H, Random, 95% CI) |
0.49 [0.25, 0.96] |
| 7.3 Beta lactum (including co‐amoxiclav) versus placebo |
2 |
1880 |
Risk Ratio (M‐H, Random, 95% CI) |
0.78 [0.52, 1.16] |
| 7.4 Macrolide (including erythromycin) versus placebo |
4 |
2136 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.60, 1.44] |
| 7.5 Other antibiotic versus placebo |
4 |
823 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.45, 1.64] |
| 8 Birth before 37 weeks' gestation |
3 |
4931 |
Risk Ratio (M‐H, Random, 95% CI) |
1.00 [0.98, 1.03] |
| 9 Major adverse drug reaction |
3 |
5487 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 10 Maternal infection after delivery prior to discharge |
4 |
5547 |
Risk Ratio (M‐H, Random, 95% CI) |
0.91 [0.80, 1.02] |
| 11 Chorioamnionitis |
11 |
1559 |
Risk Ratio (M‐H, Random, 95% CI) |
0.66 [0.46, 0.96] |
| 12 Caesarean section |
11 |
6317 |
Risk Ratio (M‐H, Random, 95% CI) |
0.96 [0.88, 1.05] |
| 13 Days from birth till discharge of mother |
0 |
0 |
Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 14 Days from randomisation to birth |
0 |
0 |
Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 15 Birth within 48 hours of randomisation |
7 |
5927 |
Risk Ratio (M‐H, Random, 95% CI) |
0.71 [0.58, 0.87] |
| 16 Birth within 7 days of randomisation |
7 |
5965 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.71, 0.89] |
| 17 Birthweight |
12 |
6374 |
Mean Difference (IV, Random, 95% CI) |
53.83 [7.06, 100.60] |
| 18 Birthweight < 2500 g |
2 |
4876 |
Risk Ratio (M‐H, Random, 95% CI) |
1.00 [0.96, 1.04] |
| 19 Neonatal intensive care |
4 |
5023 |
Risk Ratio (M‐H, Random, 95% CI) |
0.98 [0.84, 1.13] |
| 20 Days in neonatal intensive care unit |
3 |
225 |
Mean Difference (IV, Random, 95% CI) |
‐5.05 [‐9.77, ‐0.33] |
| 21 Positive neonatal blood culture |
3 |
4961 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.63, 0.99] |
| 22 Neonatal respiratory distress syndrome |
12 |
6287 |
Risk Ratio (M‐H, Random, 95% CI) |
0.95 [0.83, 1.09] |
| 23 Treatment with surfactant |
1 |
4809 |
Risk Ratio (M‐H, Random, 95% CI) |
0.83 [0.72, 0.96] |
| 24 Number of babies requiring ventilation |
2 |
4924 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.80, 1.02] |
| 25 Number of babies requiring oxygen therapy |
1 |
4809 |
Risk Ratio (M‐H, Random, 95% CI) |
0.88 [0.81, 0.96] |
| 26 Neonatal oxygenation > 28 days |
3 |
5487 |
Risk Ratio (M‐H, Random, 95% CI) |
0.79 [0.61, 1.03] |
| 27 Neonatal encephalopathy |
1 |
60 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 28 Serious childhood disability at 7 years |
1 |
3171 |
Risk Ratio (M‐H, Random, 95% CI) |
1.01 [0.91, 1.12] |
