Comparison 1. Aminoglycosides and antianaerobes versus any other regimens.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality (all causes)	5	581	Odds Ratio (M‐H, Random, 95% CI)	2.03 [0.88, 4.71]
2 Mortality (all causes ‐ ITT analysis)	3	747	Odds Ratio (M‐H, Random, 95% CI)	2.10 [0.78, 5.65]
3 Mortality (due to infection)	5	541	Odds Ratio (M‐H, Random, 95% CI)	1.51 [0.66, 3.43]
4 Clinical success	19	1956	Odds Ratio (M‐H, Random, 95% CI)	0.65 [0.46, 0.92]
4.1 Overall	13	1336	Odds Ratio (M‐H, Random, 95% CI)	0.57 [0.41, 0.78]
4.2 Appendix	6	620	Odds Ratio (M‐H, Random, 95% CI)	1.36 [0.44, 4.14]
5 Clinical success (ITT analysis)	1	160	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.15, 1.43]
5.1 Overall	1	160	Odds Ratio (M‐H, Random, 95% CI)	0.47 [0.15, 1.43]
6 Microbiological success	6	579	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.31, 0.76]
7 Microbiological success (ITT analysis)	1	139	Odds Ratio (M‐H, Random, 95% CI)	0.94 [0.40, 2.20]
8 Wound infection	9	913	Odds Ratio (M‐H, Random, 95% CI)	0.84 [0.35, 2.02]
9 Intra‐abdominal abscess	7	677	Odds Ratio (M‐H, Random, 95% CI)	0.85 [0.40, 1.83]
10 Clinical sepsis	2	195	Odds Ratio (M‐H, Random, 95% CI)	1.46 [0.07, 31.21]
11 Remote infection	1	112	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.37, 3.47]
12 Superinfection	3	401	Odds Ratio (M‐H, Random, 95% CI)	2.15 [0.89, 5.17]
13 Adverse reactions	7	707	Odds Ratio (M‐H, Random, 95% CI)	1.76 [0.87, 3.53]
13.1 Overall	3	340	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.31, 3.44]
13.2 Major adverse reactions	1	76	Odds Ratio (M‐H, Random, 95% CI)	3.60 [0.62, 21.06]
13.3 Minor adverse reactions	3	291	Odds Ratio (M‐H, Random, 95% CI)	2.32 [0.89, 6.06]
14 Adverse reactions (ITT analysis)	4	625	Odds Ratio (M‐H, Random, 95% CI)	0.69 [0.43, 1.11]
14.1 Overall	3	529	Odds Ratio (M‐H, Random, 95% CI)	0.84 [0.49, 1.47]
14.2 Minor adverse reactions	1	96	Odds Ratio (M‐H, Random, 95% CI)	0.40 [0.16, 1.00]
15 Duration of therapy	6	567	Mean Difference (IV, Random, 95% CI)	0.37 [‐0.05, 0.80]
16 Days hospitalised	5	490	Mean Difference (IV, Random, 95% CI)	0.57 [0.06, 1.07]
17 TIme to defervescence	5	490	Mean Difference (IV, Random, 95% CI)	0.38 [‐0.29, 1.05]