Table 3.
Results of multivariate analysis of PFS and OS
| Covariate | PFS, years | OS, years | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age, years | ||||
| ≥ 70 | 1.01 (0.72–1.41) | 0.974 | 1.75 (1.21–2.57) | 0.003* |
| < 70 | 1 (Ref) | 1 (Ref) | ||
| Sex | ||||
| Male | 1.322 (0.73–2.40) | 0.358 | 1.63 (0.78–3.40) | 0.193 |
| Female | 1 (Ref) | 1 (Ref) | ||
| Smoking status | ||||
| ≥ 20 pack/year | 1.42 (0.89–2.26) | 0.144 | 1.45 (0.78–2.67) | 0.240 |
| < 20 pack/year | 1 (Ref) | 1 (Ref) | ||
| ECOG | ||||
| ≥ 2 | 1.23 (0.98–2.13) | 0.061 | 1.33 (0.69–2.56) | 0.401 |
| 0–1 | 1 (Ref) | 1 (Ref) | ||
| T | ||||
| T3–4 | 1.09 (0.81–1.47) | 0.574 | 1.11 (0.76–1.61) | 0.594 |
| T1–2 | 1 (Ref) | 1 (Ref) | ||
| N | ||||
| N1–3 | 1.71 (0.93–3.15) | 0.086 | 1.47 (0.75–2.88) | 0.267 |
| N0 | 1 (Ref) | 1 (Ref) | ||
| M | ||||
| M1 | 1.73 (1.27–2.34) | 0.0005* | 1.42 (0.99–2.04) | 0.060 |
| M0 | 1 (Ref) | 1 (Ref) | ||
| Prior radiotherapy | ||||
| Yes | 0.77 (0.57–1.05) | 0.093 | 0.69 (0.48–0.99) | 0.046* |
| No | 1 (Ref) | 1 (Ref) | ||
| Tumor burden | ||||
| > 8 cm | 1.04 (1.00–1.09) | 0.054 | 1.09 (1.03–1.15) | 0.002* |
| ≤ 8 cm | 1 (Ref) | 1 (Ref) | ||
| TSR | ||||
| ≥ − 6.6% | 1.13 (1.09–1.17) | 1.24E−12* | 1.14 (1.09–1.18) | 2.87E−10* |
| < − 6.6% | 1 (Ref) | 1 (Ref) | ||
CI: confidence interval; ECOG: Eastern Cooperative Oncology Group; HR: hazard ratio; OS: overall survival; PFS: progression-free survival; TSR: tumor shrinkage rate