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. 2024 Aug 2;24:881. doi: 10.1186/s12903-024-04667-y

Fig. 2.

Fig. 2

(a) Representative images of the iodine-starch sweat test on rat hind feet at 1 h after the topical and oral administration. Black dots represent sweating spots. a-1: SSG, a-2: SBN, a-3: PO, a-4: NT. (b) Time course of sweat dots before and after the topical and oral administration of pilocarpine in rats. Circles, squares, triangles, and open rhombuses represent SSG, SBN, PO, and NT groups, respectively (n = 6 per group). Each point represents the mean ± standard deviation. *p < 0.05, **p < 0.01, and ***p < 0.001 for each point versus before administration in the PO group. NT, non-treated; PO, pilocarpine administered orally; SBN, pilocarpine ointment applied to the skin on the back of neck; SSG, pilocarpine ointment applied to the skin over the salivary glands