Table 1.

Tissue-to-plasma partition coefficients of pilocarpine in the rat salivary glands (K_{p, SG}) after pilocarpine ointment application

	0.5 h	3 h	12 h
PO	7.5 ± 5.2	4.7 ± 9.9	―
SBN	―	1.9 ± 0.7	2.4 ± 1.9
SSG	690.6 ± 1072.5	60.0 ± 49.7*	45.5 ± 28.5††

n = 2–6 (excluding values below the limit of quantitation). Data are shown as mean ± standard deviation. PO, orally administered pilocarpine; SBN, pilocarpine ointment applied to the skin on the back of the neck; SSG, pilocarpine ointment applied to the skin over the salivary glands. *p < 0.05 compared with the PO group, ^††p < 0.01 compared with the SBN group