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Schematic illustration of the mechanisms underlying the cardioprotective effects of MC-ELNs via stabilizing p62 expression. Doxorubicin led to p62 ubiquitination proteasomal degradation in cardiomyocytes. MC-ELNs stabilized p62 expression to promote its competition with Nrf2 for Keap1 binding, promoting nuclear translocation of Nrf2 and its downstream gene HO-1 activation. MC-ELNs, Momordica charantia L.-derived exosome-like nanovesicles
