Table 5.
Concomitant effect of NT-proBNP and Echocardiographic Abnormalities on Health Status, Physical Activity and Cardiopulmonary Exercise Testing
| Grouping | p-value | ||||
|---|---|---|---|---|---|
| Normal Echo† Low NT-proBNP |
Abnormal Echo* Low NT-proBNP |
Normal Echo† High NT-proBNP |
Abnormal Echo * High NT-proBNP |
||
| n | 191 | 150 | 211 | 133 | |
| KCCQ physical limitation score, mean (SD) | 91.61 (13.83) | 89.42 (16.66) | 86.80 (18.62) | 88.27 (15.74) | 0.03 |
| KCCQ clinical summary score, mean (SD) | 92.54 (12.89) | 91.17 (13.50) | 88.42 (16.17) | 90.38 (12.91) | 0.03 |
| KCCQ overall summary score, mean (SD) | 92.07 (13.24) | 90.56 (14.15) | 87.89 (17.45) | 90.26 (12.63) | 0.04 |
| PASE score. mean (SD) | 177.43 (101.71) | 151.88 (89.78) | 144.04 (82.65) | 141.94 (78.61) | 0.001 |
| Duration of CPET test, min, mean (SD) | 10.23 (2.35) | 10.27 (2.42) | 9.26 (2.19) | 9.26 (2.53) | < 0.001 |
| Peak VO2, mL/Kg/min, mean (SD) | 16.61 (3.79) | 16.40 (3.77) | 15.07 (3.62) | 14.74 (3.75) | < 0.001 |
| VE/VCO2 slope, mean (SD) | 30.43 (4.88) | 31.01 (4.94) | 31.75 (6.00) | 31.73 (5.50) | 0.06 |
| Peak respiratory exchange rate, mean (SD) | 1.18 (0.10) | 1.18 (0.10) | 1.18 (0.10) | 1.17 (0.09) | 0.86 |
*Abnormal ECHO defined as Myocardial Global Longitudinal Strain < − 16 or left ventricular mass index > 95 for females or > 115 for males or E/e’ >13 or left atrial volume index > 34. † Normal ECHO is defined as the absence of these abnormalities. Low NT-proBNP is defined as < 71 ng/L while high NT-proBNP is defined as ≥ 71 ng/L
NT-proBNP, N-terminal pro-B-type natriuretic peptide; KCCQ, Kansas City Cardiomyopathy Questionnaire; PASE, physical activity scale for the elderly; SD, standard deviation; CPET, cardiopulmonary exercise testing; VO2, maximal oxygen consumption; VE/VCO2, ventilatory efficiency