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. 2024 Aug 3;10:144. doi: 10.1038/s41531-024-00761-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The scatter plot shows results from DEA performed on LRRK2 interactors; LRRK2-PD (LRRK2-G2019S) cases vs. Controls. Interactors with significant alterations (|log2FC| > 0.05 & adjusted-p < 0.05) are colour coded as blue (down-regulated) and red (up-regulated) dots. B, C The bubble graphs show the enriched GO-BPs for up-regulated and down-regulated LRRK2 interactors; LRRK2-PD cases vs. Controls. The colour of the bubble represents enrichment significance (−log10(adjusted-p)), while bubble size represents enrichment ratio (intersection size/query size).