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. 2024 Aug 3;10:144. doi: 10.1038/s41531-024-00761-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The network graphs show the significant downregulation of Cluster A in sPD (A) and LRRK2-PD (B), in which LRRK2 interactors are represented as nodes (N = 45) while PPIs are represented as edges (N = 115). Edges are represented with a continuous red line if they are up-regulated, with a dotted blue line if they are down-regulated. The thickness of the edges refers to the level of alterations of PPIs: the line is thicker if the 2 interactors connected by a given edge exhibited both the same trend of alteration (i.e, both up-regulated or down-regulated in PD cases vs. Controls).