Table 6.
First 15 functional groups (lower adjusted p-value through Benjamini–Hochberg correction) of biological processes enriched for cluster of mEV miRNA targets. For Clusters 7, and 9–15, no statistically significant enriched terms were found.
| mEV miRNA targets | Function | Group adjusted p-value | No. of terms | Groups |
|---|---|---|---|---|
|
Cluster1 HYRC |
Blood vessel endothelial cell migration | 4.20E−07 | 10 | Group12 |
| Peptidyl-serine modification | 4.80E−07 | 2 | Group03 | |
| Protein autophosphorylation | 1.48E−06 | 4 | Group10 | |
| Autophagosome organization | 1.81E−06 | 3 | Group09 | |
| Hematopoietic progenitor cell differentiation | 2.03E−06 | 6 | Group11 | |
| Negative regulation of neuron death | 2.49E−06 | 2 | Group05 | |
| Regulation of cardiac muscle hypertrophy | 2.26E−04 | 2 | Group02 | |
| Cellular response to amyloid-beta | 7.95E−04 | 1 | Group01 | |
| Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 8.44E−04 | 2 | Group04 | |
| Regulation of protein acetylation | 1.49E−03 | 2 | Group07 | |
| Cellular response to angiotensin | 4.32E−03 | 2 | Group08 | |
| Columnar/cuboidal epithelial cell differentiation | 4.56E−03 | 2 | Group06 | |
| Regulation of T cell migration | 8.40E−03 | 1 | Group00 | |
|
Cluster2 RGR1-SUR2-ARC77-ARC70-ARC34 |
Positive regulation of transcription initiation from RNA polymerase II promoter | 3.00E−40 | 8 | Group20 |
| Transcription initiation from RNA polymerase II promoter | 2.33E−35 | 15 | Group23 | |
| Transcription coregulator activity | 6.63E−29 | 3 | Group13 | |
| RNA polymerase II general transcription initiation factor activity | 1.14E−17 | 21 | Group24 | |
| Histone H3 acetylation | 2.00E−11 | 4 | Group17 | |
| DNA-directed 5'-3' RNA polymerase activity | 9.68E−11 | 2 | Group10 | |
| snRNA transcription by RNA polymerase II | 6.01E−07 | 5 | Group18 | |
| Regulation of DNA recombination | 5.89E−06 | 12 | Group21 | |
| Signal transduction by p53 class mediator | 3.54E−05 | 13 | Group22 | |
| Regulation of telomere maintenance | 1.60E−04 | 4 | Group16 | |
| Intracellular steroid hormone receptor signaling pathway | 4.13E−04 | 2 | Group12 | |
| Positive regulation of attachment of mitotic spindle microtubules to kinetochore | 1.45E−03 | 5 | Group19 | |
| Regulation of cyclin-dependent protein serine/threonine kinase activity | 2.10E−03 | 2 | Group08 | |
| Maintenance of protein location in nucleus | 2.68E−03 | 1 | Group01 | |
| Mitochondrial membrane organization | 2.74E−03 | 4 | Group15 | |
|
Cluster3 MLR2 |
Histone H3-K27 methylation | 2.46E−06 | 9 | Group3 |
| Positive regulation of amyloid precursor protein catabolic process | 3.52E−04 | 3 | Group1 | |
| Low-density lipoprotein particle receptor activity | 8.11E−04 | 1 | Group0 | |
| Positive regulation of establishment of protein localization to telomere | 9.44E−04 | 9 | Group2 | |
|
Cluster4 KIAA0928 |
mRNA metabolic process | 3.68E−26 | 20 | Group10 |
| Regulation of mRNA metabolic process | 2.32E−25 | 11 | Group08 | |
| Regulation of cellular macromolecule biosynthetic process | 5.24E−23 | 6 | Group07 | |
| Gene silencing by RNA | 8.08E−21 | 16 | Group09 | |
| Negative regulation of cellular amide metabolic process | 8.02E−20 | 3 | Group04 | |
| RNA transport | 5.89E−12 | 6 | Group06 | |
| Translational initiation | 1.16E−08 | 3 | Group03 | |
| Nuclear-transcribed mRNA catabolic process | 2.04E−08 | 3 | Group02 | |
| Regulation of type I interferon-mediated signaling pathway | 4.39E−05 | 3 | Group05 | |
| Positive regulation of mRNA splicing. via spliceosome | 3.20E−04 | 1 | Group00 | |
| Spliceosomal snRNP assembly | 9.07E−04 | 1 | Group01 | |
|
Cluster5 HERC2 |
Translation initiation factor activity | 2.77E−11 | 2 | Group2 |
| Intermediate filament organization | 7.01E−04 | 1 | Group0 | |
| Iron ion homeostasis | 1.14E−03 | 1 | Group1 | |
| Negative regulation of TOR signaling | 1.21E−03 | 3 | Group3 | |
|
Cluster6 SP1 |
Cellular response to transforming growth factor beta stimulus | 6.70E−09 | 7 | Group5 |
| miRNA transcription | 2.15E−06 | 2 | Group3 | |
| Negative regulation of protein modification by small protein conjugation or removal | 4.94E−05 | 2 | Group4 | |
| Regulation of DNA-templated transcription in response to stress | 1.94E−04 | 1 | Group1 | |
| Regulation of intracellular steroid hormone receptor signaling pathway | 5.68E−04 | 1 | Group0 | |
| Cardiac muscle tissue morphogenesis | 3.10E−03 | 1 | Group2 | |
|
Cluster8 APOB |
Regulation of polysaccharide biosynthetic process | 6.94E−06 | 3 | Group1 |
| Retrograde protein transport. ER to cytosol | 2.10E−05 | 1 | Group0 |