TABLE 1.
In vitro activity of chalcones (1aa–bg) and bichalcones (2aa–bg) against Toxoplasma gondii ME49 tachyzoites. Values shown in the table represent the means of three independent experiments each done in duplicate (n = 6) ± S.D.
| Chalcone | IC50 ± S.D. (µM) | Bichalcone | IC50 ± S.D. (µM) |
|---|---|---|---|
| 1aa | 21.81 ± 3.07 | 2aa | 6.63 ± 0.77 |
| 1ab | 14.05 ± 2.62 | 2ab | 0.11 ± 0.02 |
| 1ac | >50 | 2ac | >50 |
| 1ad | >50 | 2ad | 24.74 ± 3.52 |
| 1ae | 10.60 ± 1.05 | 2ae | 7.91 ± 1.14 |
| 1af | 6.18 ± 0.55 | 2af | 30.48 ± 7.21 |
| 1ag | >50 | 2ag | 18.44 ± 0.10 |
| 1ba | 8.08 ± 2.06 | 2ba | >50 |
| 1bb | 6.01 ± 2.54 | 2bb | 9.75 ± 1.95 |
| 1bc | >50 | 2bc | >50 |
| 1bd | >50 | 2bd | 3.09 ± 0.15 |
| 1be | >50 | 2be | 8.55 ± 1.28 |
| 1bf | 11.32 ± 0.61 | 2bf | 12.4 ± 2.09 |
| 1bg | 4.46 ± 0.46 | 2bg | >50 |