TABLE 2.
In vitro cytotoxicity of chalcones (1aa–bg) and bichalcones (2aa–bg) on human fibroblasts Hs27 and their selectivity indexes (SI) Values shown in the table represent the means of three independent experiments each done in duplicate (n = 6).
| Chalcone | CC50 (µM) | SI | Bichalcone | CC50 (µM) | SI |
|---|---|---|---|---|---|
| 1aa | 179.7 ± 32 | 8.2 | 2aa | >200 | >30 |
| 1ab | 132.8 ± 28 | 13.2 | 2ab | >200 | >6,994 |
| 1ac | >200 | – | 2ac | >200 | – |
| 1ad | >200 | – | 2ad | >200 | >8 |
| 1ae | 190.3 ± 99 | 18 | 2ae | >200 | >25 |
| 1af | 133.8 ± 78 | 21.7 | 2af | >200 | >7 |
| 1ag | >200 | – | 2ag | >200 | >11 |
| 1ba | >200 | >25 | 2ba | >200 | – |
| 1bb | 87.8 ± 16 | 14.6 | 2bb | >200 | >21 |
| 1bc | >200 | – | 2bc | >200 | – |
| 1bd | >200 | – | 2bd | >200 | >65 |
| 1be | >200 | – | 2be | >200 | >23 |
| 1bf | >200 | >18 | 2bf | >200 | >16 |
| 1bg | 86.5 ± 72 | 29.8 | 2bg | >200 | – |