Table 2.
MIC values of honokiol combined with β-lactam antibiotics against drug-resistant S. aureus.
| Strain a | Compound | MIC (Single compound, μg/mL) | MIC (Checkerboard assay, μg/mL) | FICI |
|---|---|---|---|---|
| ATCC 29247 | Honokiol | 4 | 1 | 0.5 |
| Ampicillin | 24 | 6 | ||
| ATCC BAA-41 | Honokiol | 4 | 1 | 0.5 |
| Ampicillin | 48 | 12 | ||
| ATCC BAA-41 | Honokiol | 4 | 1 | 0.3125 |
| Methicillin | 1,024 | 64 | ||
| ATCC BAA-41 | Honokiol | 4 | 1 | 0.375 |
| Oxacillin | 256 | 32 | ||
| ATCC BAA-41 | Honokiol | 4 | 2 | 0.75 |
| Imipenem | 24 | 6 | ||
| ATCC BAA-41 | Honokiol | 4 | 2 | 0.75 |
| Ceftazidime | 96 | 24 |
a
ATCC 29247 is an ampicillin-resistant S. aureus. ATCC BAA-41 is an MRSA.