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. 2024 Jul 22;6:1425537. doi: 10.3389/ftox.2024.1425537

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Copyright © 2024 Rericha, St. Mary, Truong, McClure, Martin, Leonard, Thunga, Simonich, Waters, Field and Tanguay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphological effects of PFAS exposures and phenotypically anchored transcriptomics. Zebrafish were exposed to PFAS at 6 h post fertilization (hpf), sampling for RNA sequencing performed at 48 hpf, and morphology assessments conducted at 24 and 120 hpf. PFAS for which phenotypic anchoring of transcriptomics was possible are named and numbered along the top of the figure. PFAS are listed in order (left to right) of increasing number of differentially expressed genes (DEGs), defined only by an adjusted p-value threshold of <0.05 and noted at the bottom of the figure. Average Percent Incidence of each morphological effect (y-axis) are displayed within the bubble plot, with larger bubbles signifying higher percent incidence. See Supplementary Table S1A and Supplementary Table S1B for descriptions of each morphological endpoint.