Table 2.
Median oculometric responses.
| Table 2 Functional Effects | Early Perifoveal Vision | Late Foveal Vision | Visual Motion Precision |
Visual Motion Accuracy | Subcortical Visuomotor Response | Pupillary Response | Localization | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Latency (ms) |
Acceleration (deg/s2) | Gain | Direction Noise (°) |
Speed Noise (%) |
Direction Anisotropy | Direction Asymmetry | Speed Responsiveness |
Saccadic Rate (Hz) |
Saccadic Amplitude (deg) |
Saccadic Dispersion (°) |
Proportion Smooth |
Contraction Time Constant (ms) |
Dilation Time Constant (ms) |
Mean Fixation Error (deg) |
|
| Patient Median (N = 12) | 165.5 | 90.5 | 0.76 | 9.4 | 17.5 | 0.30 | 0.01 | 0.36 | 3.53 | 2.19 | 21.4 | 0.71 | 172 | 911 | 0.73 |
| No-tox Patient Median (N = 10) | 161.5 | 90.5 | 0.79 | 9.1 | 16.8 | 0.30 | -0.09 | 0.36 | 3.29 | 2.11 | 21.4 | 0.70 | 172 | 911 | 0.68 |
| Control Median (N = 17) | 164.0 | 116.0 | 0.90 | 9.1 | 15.4 | 0.24 | 0.05 | 0.52 | 3.51 | 1.50 | 15.7 | 0.76 | 176 | 756 | 0.50 |
| p (Mann-Whitney U test) | 0.4870 0.2722 |
0.0003 0.0003 |
0.0101 0.0321 |
0.5000 0.3696 |
0.1516 0.3196 |
0.8532 0.2914 |
0.6873 0.1462 |
0.0207 0.0451 |
0.3394 0.4510 |
0.0002 0.0013 |
0.0949 0.0504 |
0.0371 0.0870 |
0.4008 0.2931 |
0.3594 0.3217 |
0.0442 0.1022 |
Note that six metrics show significant (p < 0.05) differences between the patient and control groups and that four metrics remain significantly different even when the patient group is limited to the ten without diagnosed retinal toxicity. Significant impairments (p < 0.05) are bolded and those that approach significance (p < 0.11) are italicized. Top p-values are for the comparison of controls with the full patient population of twelve, while the bottom values are for comparison with the population of ten without HCQ toxicity.