Figure 2.

Ultrastructural changes of tubule interstitium and changes in lipid pathway-related genes in UUO mouse model at 7 days. (a). Sham control kidney shows normal tubules. Peritubular capillary shows normal thickening and fenestration of endothelium (a₁). Few regular empty spaces (thick arrow) are present in the tubular epithelium (a₂) (b). UUO kidney at 7 days shows dilatation of tubule with loss brush border (arrowheads). Thickening and loss of fenestration of capillary endothelium (arrow) are also observed in UUO kidney (b₁). Many regular empty spaces (thick arrows) are present in the tubular epithelium of the UUO kidney (b₂). (c) Changes in expression levels of lipid pathway-related genes between sham control (n = 4) and UUO kidney (n = 4) at 7 days (Student t-test, one-tailed, **p < 0.01, *p < 0.05, ns: non-significant).