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. Author manuscript; available in PMC: 2024 Oct 4.
Published in final edited form as: J Neurochem. 2024 Feb 5;168(9):1923–1936. doi: 10.1111/jnc.16067

Figure 2. 6m-PS19 mice exhibit stable PNNs in the presence of pTau accumulation without gliosis.

Figure 2.

5-region stereology analysis (Bregma −1.4 to −1.8 mm) of 6-month-old PS19 mice exhibit regional accumulation of A) pTau (AT8) in the CA3 (white arrow) without changes in B) astrogliosis (GFAP), C) WFA (PNN CS-GAGs), D) ACAN (PNN CSPG), or E) microgliosis (Iba1). Scale bar: 0.5 mm, representative images from male mice, dapi included in all images. Statistics reported in Supplemental Table 3.